Cysteamine Hydrochloride → 1-Nitro-2-(2-propynylamino)-2-(2-mercaptoethyl)ethylene

HRID 894128Notes

Reaction equation

HRID 894128 reaction equation
CS[C:3]([NH:8][CH2:9][C:10]#[CH:11])=[CH:4][N+:5]([O-:7])=[O:6].Cl.N[CH2:14][CH2:15][SH:16]>>[N+:5]([CH:4]=[C:3]([NH:8][CH2:9][C:10]#[CH:11])[CH2:14][CH2:15][SH:16])([O-:7])=[O:6]

Participants

3

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 71401969N-[1-(Methylsulfanyl)-2-nitroethenyl]prop-2-yn-1-amine

Product 1

HCID 736839981-Nitro-2-(2-propynylamino)-2-(2-mercaptoethyl)ethylene

Procedure

A solution of the product of Step A of Example 2 is reacted with about an equimolar amount of cysteamine hydrochloride and about two equivalents of base, and the title product is produced.

Sources & evidence

ORD record
ord-21861c96df3b4e3aaa811e0c1fa24816
Source dataset
uspto-grants-1981_08
Patent number
US04282363

Reaction notes

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