HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Olopatadine Impurity 17
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Cyano-6,11-dihydro-11-oxodibenz[b,e]oxepin | HCID 12446825 | — |
| Solvent | Water | HCID 962 | — |
| Product | Olopatadine Impurity 17 | HCID 12446821 | — |
Reaction Steps
Reflux 27.3 gm. of 2-cyano-6,11-dihydro-11-oxodibenz[b,e]oxepin in a mixture of 300 cc. of 37% aqueous hydrochloric acid and 300 cc. of glacial acetic acid for 24 hours. Cool, dilute with water and separate the solids by filtration in order to obtain the title product (m.p. 250° C. dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04282365 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-22b50447770248b19f472dbeb7d6785f |
| Source note | uspto-grants-1981_08 |