Water → HCID 86737923, compound

Participants

Reaction Steps

Add 16.07 gm. (0.044 mole) of methyl 5-bromo-α-(3,4methylenedioxyphenoxy)-o-toluate to a solution of 3.52 gm. (0.088 mole) of sodium hydroxide in 24 ml. of water and 212 ml. of methanol. Heat the mixture under reflux for 1 hour. Remove the methanol under vacuum and dissolve the residue in 225 ml. of water. Acidify with concentrated hydrochloric acid to the congo red end point. Separate the solids by filtration and dry (yield 14.14 gm., m.p. 167°-177° C.). Recrystallize from ethanol-water to obtain pure product as tan needles (m.p. 177°-180° C.).

Provenance & Evidence