HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Olopatadine Impurity 17 | HCID 12446821 | — |
| Product | 2-Chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin | HCID 13456005 | — |
Reaction Steps
Heat a solution of 5 gm. of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid and 40 ml. of thionyl chloride under reflux for 20 minutes. Evaporate the reaction mixture under vacuum to dryness. Repeat the evaporation with two 30 ml. portions of carbon tetrachloride. Crystallize the residue from diisopropyl ether to obtain the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04282365 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-03917c48796442249d1cb806af3c04d1 |
| Source note | uspto-grants-1981_08 |