反应详情

To a stirred solution of 1.0 gm of 2-chlorocarbonyl-6,11-dihydro-11-oxo-dibenz[b,e]oxepin in 50 cc of methylene chloride, add 3 gm of ethylene glycol and stir the mixture for 18 hours at room temperature. Distill off the solvent and excess ethylene glycol under high vacuum (0.1 mm). Chromatograph the residue on a silica gel column (100 gm), eluting with 10% ethyl acetate in benzene to obtain the title product.

1. distillationDistill off the solvent and excess ethylene glycol under high vacuum (0.1 mm)
2. washChromatograph the residue on a silica gel column (100 gm), eluting with 10% ethyl acetate in benzene