HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxypropionic acid → beta-Carboxyethyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxypropionic acid | HCID 68152 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-Chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin | HCID 13456005 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | beta-Carboxyethyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylate | HCID 21162729 | — |
Reaction Steps
Dissolve 1.0 gm of 2-chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin in 20 cc of tetrahydrofuran and add 1.0 gm of the sodium salt of β-hydroxypropionic acid. Stir the mixture at room temperature for 18 hours. Filter and evaporate the filtrate to dryness. Recrystallize the solid residue from ethanol to obtain the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04282365 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-1bf56c2a8e9b47169a1b159c92fee450 |
| Source note | uspto-grants-1981_08 |