HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Olopatadine Impurity 17 | HCID 12446821 | — |
| Product | Methyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepine-2-carboxylate | HCID 2769045 | — |
Reaction Steps
Reflux 8 gm. of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid in 600 cc. of methanol containing 1 cc. of sulfuric acid for 19 hours. Cool and separate the solids by filtration to obtain the title product. (m.p. 130°-131° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04282365 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-30f34042357f43259b8dfc9308f9c021 |
| Source note | uspto-grants-1981_08 |