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Tetrahydrofuran → 6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 11-hydroxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate | HCID 2769059 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid | HCID 12929144 | — |
反応手順
Dissolve 900 mg. of methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate in 20 cc. of tetrahydrofuran. Add 20 cc. 1 N aqueous sodium hydroxide. Stir at room temperature for 48 hours. Dilute with water and extract with ether. Acidify the aqueous fraction with hydrochloric acid and extract with ether. Evaporate the organic phase to obtain the title product (m.p. 275° C. dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04282365 |
| 出典データセット | uspto-grants-1981_08 |
| ORD ID | ord-06261300041049b7ae1e5f982962a19a |
| 出典メモ | uspto-grants-1981_08 |