Thionyl Chloride → HCID 10446851, compound

HRID 894201Notes

Reaction equation

HRID 894201 reaction equation
O[CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([O:19][CH3:20])=[O:18])=[CH:16][C:3]1=2.[S:21]([Cl:24])([Cl:23])=[O:22]>C1C=CC=CC=1>[S:21]([Cl:24])([Cl:23])=[O:22].[Cl:23][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([O:19][CH3:20])=[O:18])=[CH:16][C:3]1=2

Participants

5

Reactant 2

HCID 24386Thionyl Chloride2×HCID 2769059Methyl 11-hydroxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate

Product 2

HCID 24386Thionyl ChlorideHCID 10446851HCID 10446851, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Reflux 3.14 gm. of methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate and 15 cc. of thionyl chloride for 10 minutes. Evaporate excess thionylchloride. Remove traces of thionyl chloride by co-distillation with benzene to obtain the title product (yield 3.35 gm., 100%).

Workup

  1. temperatureReflux 3.14 gm

Sources & evidence

ORD record
ord-51e939ef08144fca9efef3a01791fcd8
Source dataset
uspto-grants-1981_08
Patent number
US04282365

Reaction notes

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