Sodium Hydroxide → HCID 21162752, compound

HRID 894210Notes

Reaction equation

HRID 894210 reaction equation
[C:1]1([S:7][CH:8]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[CH2:12][O:11][C:10]3[CH:19]=[CH:20][C:21]([C:23]([O:25]C)=[O:24])=[CH:22][C:9]2=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO.O>[C:1]1([S:7][CH:8]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[CH2:12][O:11][C:10]3[CH:19]=[CH:20][C:21]([C:23]([OH:25])=[O:24])=[CH:22][C:9]2=3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 21162740HCID 21162740, compound

Product 1

HCID 21162752HCID 21162752, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Dissolve 650 mg of the ester of Step A in 15 ml of methanol. Add 10 ml of 20% aqueous sodium hydroxide and reflux for 10 minutes. Dilute with 200 ml of water and extract with ether. Acidify the aqueous extract concentrated hydrochloric acid and extract into ether. Evaporate to dryness and crystalline from methanol to obtain the title product.

Workup

  1. temperaturereflux for 10 minutes
  2. extractionextract with ether
  3. extractionaqueous extract concentrated hydrochloric acid
  4. extractionextract into ether
  5. customEvaporate to dryness and crystalline from methanol

Sources & evidence

ORD record
ord-684631c5e44c411ea4643795e03e8c91
Source dataset
uspto-grants-1981_08
Patent number
US04282365

Reaction notes

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