Formic Acid → HCID 21162747, compound

HRID 894216Notes

Reaction equation

HRID 894216 reaction equation
[NH2:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:3]1=2.[CH:20](O)=[O:21]>>[CH:20]([NH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:3]1=2)=[O:21]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 12929150HCID 12929150, compound

Product 1

HCID 21162747HCID 21162747, compound

Procedure

Add to a mixture of 1.77 gm. (5 mmole) of 6,11-dihydro-11-aminodibenz[b,e]oxepin-2-carboxylic acid in 5 ml. of 90% formic acid, 1.5 gm. of aceticformic anhydride* at 10° C. with stirring. After 1 hour allow the mixture to warm to room temperature and continue stirring for 3 hours. Remove the volatiles by evaporation in vacuo to obtain the title product.

Workup

  1. additionAdd to a mixture of 1.77 gm
  2. customat 10° C.
  3. stirringcontinue stirring for 3 hours
  4. customRemove the volatiles
  5. customby evaporation in vacuo

Sources & evidence

ORD record
ord-e528375e9a5441ef9e32fd298d1f51dc
Source dataset
uspto-grants-1981_08
Patent number
US04282365

Reaction notes

Loading…