HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 11-Methylene-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 11-methylene-6,11-dihydrodibenz-[b,e]oxepin-2-carboxylate | HCID 10106958 | — |
| Solvent | Water | HCID 962 | — |
| Product | 11-Methylene-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid | HCID 12929133 | — |
Reaction Steps
Dissolve the residue of Step A above in 40 ml. of ethanol with warming. Cool and add 40 ml. of 20% aqueous sodium hydroxide solution. Allow to stand for 2 hour and strip away the alcohol. Dilute with water and acidify with 5 N hydrochloric acid. Separate the solids by filtration and dry to obtain the title product (yield 850 mg). Purify by recrystallization from ethanol (m.p. 255°-257° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04282365 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-62a317d984554c198ba024376fbf0ee7 |
| Source note | uspto-grants-1981_08 |