p-Toluenesulfonic acid → 1-(3,5-Dichloro-2-hydroxyphenyl)-1-(5-fluoro-2-hydroxy phenyl) ethane

Participants

Reaction Steps

2,4-Dichloro-6-(1'-hydroxyethyl)phenol (10 g) was added in small portions to a melt of 4-fluoro phenol containing a trace of p-toluenesulphonic acid at 90° over a half hour period. The reaction mixture was stirred for a further 1/2 hr and cooled. The crystallization from benzene gave 1-(3,5-dichloro-2-hydroxyphenyl)-1-(5-fluoro-2-hydroxy phenyl) ethane (11 g, m.p. 150°).

Provenance & Evidence