HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodothiophene → 5-Phenoxy-2-thiophenecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodothiophene | HCID 18921 | — |
| Reactant | Phenolate | HCID 119047 | — |
| Reactant | 1-Hydroxyethyl radical | HCID 119440 | — |
| Reactant | Methoxide | HCID 3826051 | — |
| Reactant | HCID 21162480 | HCID 21162480 | — |
| Product | 5-Phenoxy-2-thiophenecarboxylic acid | HCID 22350506 | — |
Reaction Steps
The latter compounds are alternatively prepared by reaction of 2-iodothiophene with methoxide, ethoxide or phenoxide, followed by carbonylation according to Sice [J. Am. Chem. Soc. 75, 3697 (1953)], or by alkylation of 5-hydroxythiophene-2-carboxylic acid by the method of Gronowitz [Ankiv Kemi 12, 239 (1958); Chem. Abstr. 52, 20115].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04282246 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-e65309565c214cd386596b29dd2030d8 |
| Source note | uspto-grants-1981_08 |