反应详情

Following the procedure of Example 9, o-isopropylthiophenol [4.77 g., 31.4 mmoles; Hansch and Blondon, J. Am. Chem. Soc. 70, 1561 (1948)] was reacted with 5-bromofuran-3-carboxylic acid. Rather than recover the initial crude product by filtration, the mixture was reextracted with ethyl acetate, the ethyl acetate back-washed with water and saturated brine, dried over anhydrous sodium sulfate and evaporated to yield crude product. Recrystallization from hexane produced purified 5-(2-isopropylphenylthio)furan (785 mg., m.p. 117°-120° C., m/e 262).

1. customRather than recover the initial crude product
2. filtrationby filtration
3. washthe ethyl acetate back-washed with water and saturated brine
4. dry with materialdried over anhydrous sodium sulfate
5. customevaporated
6. customto yield crude product
7. customRecrystallization from hexane
8. customproduced
9. custompurified 5-(2-isopropylphenylthio)furan (785 mg., m.p. 117°-120° C., m/e 262)