HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzenethiol → 5-(4-Methoxyphenylthio)furan-3-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzenethiol | HCID 12765 | — |
| Reactant | 5-Bromofuran-3-carboxylic acid | HCID 13333560 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(4-Methoxyphenylthio)furan-3-carboxylic Acid | HCID 21162481 | 42.5% |
Reaction Steps
By the procedure of Example 11, p-methoxythiophenol (4.39 g., 31.4 mmoles) and cuprous oxide (2.25 g., 15.7 mmoles) heated at 135° C. for 2 hours were reacted with 5-bromofuran-3-carboxylic acid (3 g., 15.7 mmoles) in 60 ml. of dimethylformamide, and crude product (1.67 g. ) isolated. Recrystallization from methylene chloride/hexane gave purified 5-(4-methoxphenylthio)furan-3-carboxylic acid (825 mg., m.p. 115°-117° C., m/e 250).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04282246 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-bb67572cc0a94d64a0227eca8f486944 |
| Source note | uspto-grants-1981_08 |