3-(Trifluoromethyl)benzenethiol → HCID 21162545, compound

Participants

Reaction Steps

By the procedure of Example 13, m-trifluoromethylthiophenol (5.59 g., 31.4 mmoles) was reacted with 5-bromofuran-3-carboxylic acid. Isolation according to Example 16 gave crude product (1.0 g.) as a gummy solid. The latter was chromatographed on silica gel with ethyl acetate-1/hexane-5/5% acetic acid as eluant. Clean middle fractions were combined and evaporated to solid product (550 mg.). Recrystallization from hexane gave purified 5-(3-trifluoromethylphenylthio)furan-3-carboxylic acid (310 mg., m.p. 99°-101° C., m/e 288).

Provenance & Evidence