反应详情

In 8 ml of methanol were dissolved 800 ml of methyl 3-[(2-guanidinothiazol-4-yl)methylthio]propionimidate and 590 mg of benzenesulfonamide and after causing reaction for 24 hours at room temperature, the solvent was distilled off under reduced pressure. The residue formed was purified by a silica gel column chromatography using a mixture of chloroform and methanol (20:1→10:1) to provide 855 mg of amorphous N-benzenesulfonyl-3-(2-guanidinothiazol-4-yl)methylthio propionamide. The product shows the following physicochemical properties:

1. customreaction for 24 hours at room temperature
2. distillationthe solvent was distilled off under reduced pressure
3. customThe residue formed
4. customwas purified by a silica gel column chromatography
5. additiona mixture of chloroform and methanol (20:1→10:1)