Methanesulfonamide → HCID 178505163, compound

HRID 894312Notes

Reaction equation

HRID 894312 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][C:14](=[NH:17])OC)[N:9]=1)[C:2]([NH2:4])=[NH:3].[CH3:18][S:19]([NH2:22])(=[O:21])=[O:20]>CO.C(O)C>[CH3:18][S:19]([NH:22][C:14](=[NH:17])[CH2:13][CH2:12][S:11][CH2:10][C:8]1[N:9]=[C:5]([NH:1][C:2]([NH2:4])=[NH:3])[S:6][CH:7]=1)(=[O:21])=[O:20]

Participants

5

Reactant 2

HCID 72879MethanesulfonamideHCID 12881442Methyl 3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]propanimidate

Product 1

HCID 178505163HCID 178505163, compoundYield 56.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

In 10 ml of methanol were dissolved 1 g of methyl 3-[(2-guanidinothiazol-4-yl)methylthio]propionimidate and 0.38 g of methanesulfonamide and after causing reaction for 48 hours at room temperature, the solvent was distilled off under reduced pressure. Then, the residue formed was dissolved in 3 ml of ethanol and the solution was allowed to cool, thereby white crystals deposited. The crystals were collected by filtration and dried to provide 0.7 g of N-methanesulfonyl-3-[(2-guanidinothiazol-4-yl)methylthio]propionamidine. The product shows the following physicochemical properties:

Workup

  1. customreaction for 48 hours at room temperature
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThen, the residue formed
  4. temperatureto cool
  5. filtrationThe crystals were collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-55f010669c4d48e5bb97bb7bc26f0921
Source dataset
uspto-grants-1981_08
Patent number
US04283408

Reaction notes

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