HCID 20575145, compound → HCID 20575169, compound

Participants

Reaction Steps

9.5 grams (0.03 mole) of 4-(di-3-thienyl-methylene)-N-methyl-piperidine hydrochloride were dissolved in 270 ml of methanol and hydrogenated in the presence of 9.5 grams of PdBaSO4 (9.25% Pd) at 65° C. and 5 bar. The purification was carried out by dry column chromatography on silica gel (elution agent: chloroform/methanol=95%/5% by volume) and recrystallization from chloroform/petroleum ether. M.P. of the hydrochloride 251°-253° C.; Yield: 11%.

Provenance & Evidence