Potassium Hydroxide → HCID 12889668, compound

Participants

Reaction Steps

A 5 g. portion of the product of Example 32 was slurried in 50 percent aqueous hydrochloric acid and refluxed overnight. The mixture was then cooled and neutralized with potassium hydroxide, and extracted with chloroform. The chloroform layer was concentrated to 10 ml., and eluted through a 12-meter column of polystyrene gel beads with chloroform as the eluting solvent. The desired product was the second fraction off the column. The yield was 2 g. of 5-aminomethyl-3-phenyl-2-isoxazoline, an oily liquid, NMR multiplets at 2.57-3.83, 4.43-4.97, 7.08-7.60 and 7.42-7.80 ppm., and a singlet at 1.38 ppm.

Provenance & Evidence