Hydrochloric Acid → HCID 12715508, compound

Participants

Reaction Steps

A clear yellow solution of methyl 2-methyl-1-oxo-3-indane acetic acid (0.844 g., 3.87 mmol) and n-butyl nitrite (1.1 ml., 9.7 mmol) [W. A. Noyes, Org. Syn., Col. Vol. II, 108 (1943)] in 7.6 ml methanol was stirred as a 5% solution of sodium methoxide in methanol. (1.2 ml., 2.6 mmol) was added. Addition of 25 ml. ether to this red-brown solution followed by 1 N hydrochloric acid to pH 3-4 precipitated the title compound which was washed with water and ether and dried: 0.40 g. (42%) mp 185°-190°.

Provenance & Evidence