反应详情

To 10 g (0.038 mole) of o-iodophenylacetic acid was added 50 ml of a solution of 5.7 g (0.048 mole) of thionyl chloride in anhydrous benzene, and the mixture was refluxed for 2 hours under agitation. Then, the solvent and unreacted thionyl chloride were removed by distillation under reduced pressure below 40° C. and the residue was subjected to distillation under reduced pressure to obtain 9.6 g of o-iodophenylacetyl chloride as a light yellow oily product having a boiling point of 153° to 156° C. under 8 mmHg in a yield of 90%.

1. temperaturethe mixture was refluxed for 2 hours under agitation
2. customThen, the solvent and unreacted thionyl chloride were removed by distillation under reduced pressure below 40° C.
3. distillationthe residue was subjected to distillation under reduced pressure