Dimethylamine → Acetamide, N,N-dimethyl-2-phenyl- (8CI)

HRID 894398Notes

Reaction equation

HRID 894398 reaction equation
[CH3:1][NH:2][CH3:3].[C:4]1([CH2:10][C:11](Cl)=[O:12])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C1C=CC=CC=1>[CH3:1][N:2]([CH3:3])[C:11](=[O:12])[CH2:10][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 7679Phenylacetyl chloride

Product 1

HCID 87853Acetamide, N,N-dimethyl-2-phenyl- (8CI)

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

In 204 ml of anhydrous benzene was dissolved 77.5 g (0.5 mole) of commercially available phenylacetyl chloride, and the solution was added dropwise to a 50% aqueous solution of 180 g (2.0 moles) of dimethyl amine, 50 g of ice and 100 ml of benzene at an inner temperature of 5° to 25° C. After completion of the dropwise addition, the mixture was agitated for 1 hour at the same temperature.

Workup

  1. additionAfter completion of the dropwise addition

Sources & evidence

ORD record
ord-ac72d7219ff64e669196200f48e4af06
Source dataset
uspto-grants-1981_08
Patent number
US04283532

Reaction notes

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