Sodium Acetate → HCID 22817078, compound

Participants

Reaction Steps

A suspension comprising a mixture of 221 mg of pyridinium chlorochromate (C5H5N+HCrO3Cl-) and 8.3 mg of sodium acetate in 1 ml of dichloromethane was prepared. To the suspension, a solution of 221 mg of 3α-(2-tetrahydropyranyloxy)-24-hydroxy-5β-cholane in 4 ml of dichloromethane was added at one time in an argon stream under stirring. After stirring for 3 hours, the supernatant of the reaction mixture was separated by decantation, and the precipitate was washed with dichloromethane three times. The supernatant was combined with the washings, passed through a short column with silica gel (4 g). The eluate with dichloromethane was concentrated under vacuum. 3α-(2-Tetrahydropyranyloxy)-24-oxo-5β-cholane (177 mg) was obtained as a colorless oily substance.

Provenance & Evidence