Water → HCID 12926278, compound

Participants

Reaction Steps

15.0 g of N-(1',2',2',2'-tetrachloroethyl)-2-acetoxybenzamide and 5.65 g of p-cresol were dissolved in 250 ml of acetone. 5.3 g of triethylamine were added dropwise thereto at a temperature below 12° C. After effecting the reaction at room temperature for 30 minutes, the reaction mixture was poured into water. 15.2 g of white N-(1'-p-methylphenoxy-2',2',2'-trichloroethyl)-2-acetoxybenzamide were obtained. The compound was suspended in 300 ml of ethanol, then 3.6 ml of concentrated hydrochloric acid were added thereto and the reaction was carried out at --60°-70° C. for three hours. After cooling, the reaction mixture was poured into water to obtain 14.3 g of N-(1'-p-methylphenoxy-2',2',2'-trichloroethyl)-2-hydroxbenzamide as white crystals. M.p. 126°-127° C.

Provenance & Evidence