Hydrochloric Acid → HCID 20574336, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 1, 30.0 g. 1-(4-chlorobenzyl)-3-hydroxy-4-phenyl-3-pyrrolin-2-one is reacted with 20.3 g. β-diethylaminoethyl chloride. The base thus obtained is converted into the crystalline hydrochloride in ethyl acetate by means of gaseous hydrogen chloride. There is obtained 24.8 g. (57% of theory) 1-(4-chlorobenzyl)-3-(β-diethylaminoethoxy)-4-phenyl-3-pyrrolin-2-one hydrochloride; m.p. 143°-145° C., after recrystallization from methyl ethyl ketone.

Provenance & Evidence