Imidazole → 1-pentylimidazole

Temperature

20 °C

n-Pentylbromide (30 ml; 0.24 mole) was added dropwise to a stirred solution of imidazole (13.6 g; 0.2 mole) in a mixture of methanol (30 ml) and sodium hydroxide solution (30 ml, 10M) maintained at 20° C. When the addition was complete the reaction mixture was stirred and refluxed for 24 hours. The solvent was evaporated, the residue extracted with chloroform (2×50 ml) and the solid remaining removed by filtration. The chloroform solution (filtrate) was dried over magnesium sulphate and concentrated to give a yellow oil which on purification gave 1-n-pentylimidazole as a colourless oil, b.p. 66°-68° C./0.15 mmHg.

1. additionWhen the addition
2. temperaturerefluxed for 24 hours
3. customThe solvent was evaporated
4. extractionthe residue extracted with chloroform (2×50 ml)
5. customthe solid remaining removed by filtration
6. dry with materialThe chloroform solution (filtrate) was dried over magnesium sulphate
7. concentrationconcentrated
8. customto give a yellow oil which
9. customon purification

ORD record

ord-6341669658d448d090460a5fc7fbfcdf

Source dataset

uspto-grants-1981_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04284641