HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(4-Difluoromethoxyphenyl)-3-methylbutyryl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(Difluoromethoxy)-alpha-(1-methylethyl)benzeneacetic acid | HCID 13118565 | — |
| Product | 2-(4-Difluoromethoxyphenyl)-3-methylbutyryl chloride | HCID 13118567 | — |
Reaction Steps
20 g of 4-difluoromethoxy-α-isopropyl-phenylacetic acid were dissolved in 100 ml of thionyl chloride and the solution was heated to the boil for 1 hour. After distilling off excess thionyl chloride, the residue was distilled under a high vacuum. 4-Difluoromethoxy-α-isopropylphenylacetic acid chloride of boiling point 93°-99° C./0.2 mm Hg was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04284643 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-93f8beaeda1141e0b7058b97dd4003b2 |
| Source note | uspto-grants-1981_08 |