Water → HCID 53844947, compound

Participants

Reaction Steps

8.1 g (0.03 mole) of 3-(2-chloro-2-phenyl-vinyl)-2,2-dimethyl-cyclopropane-carboxylic acid chloride and 6.5 g (0.03 mole) of 4-fluoro-3-phenoxy-benzaldehyde are added dropwise to a mixture of 2.25 g of sodium cyanide, 3.5 ml of water, 150 ml of n-hexane and 0.75 g of tetrabutylammonium bromide at 20° to 25° C., whilst stirring. The reaction mixture is then stirred at 20° to 25° C. for 4 hours and is subsequently diluted with 300 ml of toluene and washed twice with 300 ml of water each time. The organic phase is dried over magnesium sulphate and the solvent is distilled off under a waterpump vacuum. Last residues of solvent are removed by brief incipient distillation at 60° C./1 mbar. 10.8 g (76% of theory) of 3-(2-chloro-2-phenyl-vinyl)-2,2-dimethyl-cyclopropanecarboxylic acid 4-fluoro-3-phenoxy-α-cyano-benzyl ester are obtained as a viscous oil.

Provenance & Evidence