2-(7-Bromoimidazo[1,2-b][1,2,4]triazin-3-yl)propan-2-ol → 2'-Fluoro-5'-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile

HRID 89459Notes

Reaction equation

HRID 89459 reaction equation
[Br:25][c:26]1[cH:27][n:28][c:29]2[n:30]1[n:31][cH:32][c:33]([C:35]([CH3:36])([CH3:37])[OH:38])[n:34]2.[F:1][c:2]1[c:3](-[c:17]2[c:18]([C:23]#[N:24])[cH:19][cH:20][cH:21][cH:22]2)[cH:4][c:5]([B:8]2[O:9][C:10]([CH3:11])([CH3:12])[C:13]([CH3:14])([CH3:15])[O:16]2)[cH:6][cH:7]1>>[F:1][c:2]1[c:3](-[c:17]2[c:18]([C:23]#[N:24])[cH:19][cH:20][cH:21][cH:22]2)[cH:4][c:5](-[c:26]2[cH:27][n:28][c:29]3[n:30]2[n:31][cH:32][c:33]([C:35]([CH3:36])([CH3:37])[OH:38])[n:34]3)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 112076032-(7-Bromoimidazo[1,2-b][1,2,4]triazin-3-yl)propan-2-olHCID 117716472′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile

Product 1

HCID 99477182'-Fluoro-5'-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile

Sources & evidence

ORD record
ord-623caef9da6c4a5f818c9ccee24f6ac6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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