Propylene Oxide → HCID 14720264, compound

HRID 894598Notes

Reaction equation

HRID 894598 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].[O:12]1[CH:14]([CH3:15])[CH2:13]1>>[OH:12][CH:14]([CH3:15])[CH2:13][NH:6][C:5]1[CH:7]=[CH:8][CH:9]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=1

Participants

3

Reactant 2

HCID 6378Propylene OxideHCID 73753-(Trifluoromethyl)aniline

Product 1

HCID 14720264HCID 14720264, compoundYield 61.5%

Procedure

3-Trifluoromethylaniline is reacted with 1,2-epoxypropane as described in Example 3, Method (b), point (a) to obtain N-(β-hydroxypropyl)-3-trifluoromethyl-aniline with a yield of 61.5%; b.p.: 112°-118° C./0.5 mm Hg.

Sources & evidence

ORD record
ord-e5767c2383634382911ce60e95cecc09
Source dataset
uspto-grants-1981_08
Patent number
US04284642

Reaction notes

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