Propylene Oxide → 2-Propanol, 1-[(4-chlorophenyl)amino]-

HRID 894603Notes

Reaction equation

[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[O:9]1[CH:11]([CH3:12])[CH2:10]1>>[OH:9][CH:11]([CH3:12])[CH2:10][NH:6][C:5]1[CH:7]=[CH:8][C:2]([Cl:1])=[CH:3][CH:4]=1

Participants

Reactant 2

HCID 6378Propylene Oxide

HCID 78124-Chloroaniline

Product 1

HCID 5224602-Propanol, 1-[(4-chlorophenyl)amino]-Yield 61%

Procedure

4-Chloroaniline is reacted with 1,2-epoxypropane as described in Example 3, Method (b), point (a) to obtain N-(β-hydroxypropyl)-4-chloro-aniline with a yield of 61.0%; b.p.: 158°-164° C./0.3 mm Hg.

Sources & evidence

ORD record: ord-d29df958f743458082bf76abfc9bc533
Source dataset: uspto-grants-1981_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04284642

Reaction notes

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