Acetic Anhydride → 5-acetylaminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one

HRID 894619Notes

Reaction equation

HRID 894619 reaction equation
[NH2:1][C:2]1[CH:13]=[CH:12][C:5]2[O:6][C:7]3([C:10](=[O:11])[C:4]=2[CH:3]=1)[CH2:9][CH2:8]3.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C(O)(=O)C>[C:14]([NH:1][C:2]1[CH:13]=[CH:12][C:5]2[O:6][C:7]3([C:10](=[O:11])[C:4]=2[CH:3]=1)[CH2:9][CH2:8]3)(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 12925991HCID 12925991, compound

Product 1

HCID 129260165-acetylaminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5-Aminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one (0.875 g.) was acetylated with acetic anhydride (7 ml.) and acetic acid (7 ml.) and the acetylation product was recrystallized from ethanol. By the above procedure there was obtained 5-acetylaminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one as yellow prisms melting at 211°-212° C.

Workup

  1. customthe acetylation product was recrystallized from ethanol

Sources & evidence

ORD record
ord-05dd96b16943472b8db851c04fa5c8e2
Source dataset
uspto-grants-1981_08
Patent number
US04284644

Reaction notes

Loading…