1,4-Dibromobutane → HCID 12926027, compound

HRID 894627Notes

Reaction equation

HRID 894627 reaction equation
[NH2:1][C:2]1[C:7]2[O:8][C:9]3([C:12](=[O:13])[C:6]=2[CH:5]=[CH:4][CH:3]=1)[CH2:11][CH2:10]3.Br[CH2:15][CH2:16][CH2:17][CH2:18]Br>>[N:1]1([C:2]2[C:7]3[O:8][C:9]4([C:12](=[O:13])[C:6]=3[CH:5]=[CH:4][CH:3]=2)[CH2:10][CH2:11]4)[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 80561,4-DibromobutaneHCID 12925993HCID 12925993, compound

Product 1

HCID 12926027HCID 12926027, compoundYield 19.1%

Procedure

7-Aminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one (3.5 g) and 1,4-dibromobutane (4.3 g.) were reacted in the same manner as Example 31, and the product was recrystallized from ethanol to give 7-(1-pyrrolidinyl)spiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one (0.87 g.) as yellow needles melting at 101.5° C.

Workup

  1. customthe product was recrystallized from ethanol

Sources & evidence

ORD record
ord-b23d109e2b674f8aa416c5df7453c421
Source dataset
uspto-grants-1981_08
Patent number
US04284644

Reaction notes

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