Dimethylformamide → HCID 12926028, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-aminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one (1.75 g.) and ethylbromide (5.45 g.) and sodium hydrogen carbonate (1.68 g.) in N,N-dimethylformamide (50 ml.) was heated at 100° C. for 4 hours. The reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed with water and dried, then the solvent was evaporated off. The residue was subjected to column-chromatography on silica-gel. The first fraction eluted with hexane-ethyl acetate (97:3) was recrystallized from ethanol to give 7-diethylaminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one (0.801 g.) as yellow needles melting at 39.3° C.

Provenance & Evidence