HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitrobenzaldehyde → Piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitrobenzaldehyde | HCID 11101 | — |
| Reactant | Butanoic acid, 3-oxo-, 2-phenoxyethyl ester | HCID 12237326 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Piperidine | HCID 8082 | — |
| Product | HCID 53638503 | HCID 53638503 | — |
Reaction Steps
Starting from a mixture of 2-nitrobenzaldehyde (3.02 g), 2-phenoxyethyl acetoacetate (4.44 g), piperidine (272.5 mg) in benzene (10.8 ml) was obtained an oil (8.0 g) of 2-phenoxyethyl 2-(2-nitrobenzylidene)acetoacetate. Thus obtained oil was treated with ethyl 3-amino-4,4-diethoxycrotonate (4.34 g) to give an oil of 2-phenoxyethyl 2-methyl-4-(2-nitrophenyl)-5-ethoxycarbonyl-6-diethoxymethyl-1,4-dihydropyridine-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04284634 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-f4b35d9ad5074258b00a40010431b7bc |
| Source note | uspto-grants-1981_08 |