N-Cyclohexyl-1,3-propanediamine → N-(3'-Cyclohexylaminopropyl)-aspartic acid-4-isopropyl ester

Participants

Reaction Steps

In a manner analogous to that of Example 1, 400 ml of triethylamine are added to 350.2 g (2.0 mols+10% excess) of maleic acid-monoisopropyl ester, and the mixture is subsequently reacted with 311.3 g (2.0 mols) of 3-cyclohexylamino-1-propylamine at 59°-85° C. for 35 minutes. The reaction mixture is further processed in the manner described in Example 1 to yield 515 g (82.2% of theory) of the desired aspartic acid derivative, which decomposes at 151°-152° C.

Provenance & Evidence