N-(1,1-Dimethylethyl)-1,3-propanediamine → N-(3'-tert-Butylaminopropyl)-aspartic acid-4-ethyl ester

Participants

Reaction Steps

In a manner analogous to that of Example 1, 400 ml of triethylamine are added to 317 g (2.2 mols) of maleic acidmonoethyl ester, and the mixture is subsequently reacted with 260 g (2.0 mols) of 3-tert-butylaminopropylamine. The reaction mixture is further processed as in Example 1 to yield 423.4 g (77.2% of theory) of a white crystalline aspartic acid derivative, which melts at 174°-175° C. after recrystallisation in a mixture of ethanol/acetone (1:3).

Provenance & Evidence