Sodium Carbonate → HCID 12737476, compound

Participants

Reaction Steps

A stirred mixture of 9.5 g. of 4-chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester, 3.6 g. of N-methylpiperazine and 3.8 g. of sodium carbonate in 50 ml. of ethanol was heated under reflux for 3 hours and filtered. The filtrate was taken to dryness on a rotary evaporator leaving a thick, tarry oily residue. On triturating the oil with diethyl ether, there was obtained 9.4 g. of impure title compound, m.p. 144°-148° C. Recrystallization from ethanol gave 5.5 g. of the title compound, m.p. 154°-156° C.

Provenance & Evidence