Sodium Carbonate → HCID 12769801, compound

Participants

Reaction Steps

A mixture containing 7.1 g. of 4,6-dichloro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester, 2.36 g. of N-methylpiperazine and 2.5 g. of sodium carbonate in 25 ml. of dimethyl formamide was heated under reflux with stirring for 2 hours. The reaction mixture was cooled in ice and the resulting precipitate collected. Recrystallization from ethanol gave 4.2 g. of the title compound, m.p. 163°-165° C.

Provenance & Evidence