Morpholine → HCID 12769803, compound

HRID 894823Notes

Reaction equation

HRID 894823 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:19])[N:8]([CH3:18])[C:9]2[C:14]([C:15]=1Cl)=[CH:13][C:12]([Cl:17])=[CH:11][CH:10]=2)=[O:5])[CH3:2].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>O>[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:19])[N:8]([CH3:18])[C:9]2[C:14]([C:15]=1[N:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1)=[CH:13][C:12]([Cl:17])=[CH:11][CH:10]=2)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 12769800HCID 12769800, compound

Product 1

HCID 12769803HCID 12769803, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 200 mg. of 4,6-dichloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester, (prepared in Example 4) in 1 ml. of morpholine was heated in a test tube for a few minutes and then was poured into 40 ml. of water. The resulting precipitate was collected and washed with water. Recrystallization from ethanol gave the title compound with m.p. 167°-169° C.

Workup

  1. additionwas poured into 40 ml
  2. customThe resulting precipitate was collected
  3. washwashed with water
  4. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-45ad2d34b91e47028fa00ceca92807db
Source dataset
uspto-grants-1981_08
Patent number
US04284768

Reaction notes

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