Dimethylformamide → HCID 12769805, compound

Participants

Reaction Steps

To a solution of 8.66 g. (0.03 mole) of the sodium salt of 4-amino-6-chloro-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid ethyl ester in 50 ml. of dimethyl formamide was added 4.84 g. (0.04 mole) of allyl bromide. The reaction mixture was heated on a steam bath for 2 hours and was then cooled to room temperature. The reaction mixture was poured into 500 ml. of water. The reaction mixture was allowed to stand for several hours at room temperature and was then filtered. There was obtained 7.6 g. of product. Recrystallization from ethyl acetate gave 3.4 g. of product, m.p. 144°-146° C.

Provenance & Evidence