HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanate → Cefuroxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanate | HCID 105034 | — |
| Reactant | (6R,7R)-7-(((2Z)-2-(2-Furanyl)-2-(methoxyimino)acetyl)amino)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid | HCID 9800056 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Cefuroxime | HCID 5479529 | 77% |
Reaction Steps
A solution of (6R,7R)-7-[Z-2-(fur-2-yl)-2-methoxyiminoacetamido]-3-hydroxymethyl-ceph-3-em-4-carboxylic acid (3.84 g) in dioxan (35 ml) was added to the above isocyanate solution at ca 25°. The reaction and work up was similar to that described in Example 8, except that the product was not triturated with ether, and yielded the title compound as a pale yellow solid, (3.28 g, 77%) m.p. (M802)179°; [α]D22 +54.4° (c.1.0, DMSO).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04284767 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-02c6842c160c4ee2b1af827e02ee09dc |
| Source note | uspto-grants-1981_08 |