Sulfuric Acid → HCID 178462945, compound

Participants

Reaction Conditions

Reaction Steps

99 parts of cyanoacetic acid methyl ester are added at 5°-15° C. to 184.4 parts of a 49.4% strength aqueous solution of ethylamine, while stirring, stirring is continued for one hour, 133.5 parts of acetoacetic acid methyl ester are added and the mixture is heated at 100° C. for 5 hours in an autoclave, a pressure of 10.5 bars being generated. The reaction solution is then diluted with 600 parts of water and acidified with 74 parts of 61% strength sulphuric acid. The precipitated product is filtered off, washed and dried. This gives 153 parts (85.9% of theory) of 1-ethyl-3-cyano-4-methyl-6-hydroxypyrid-2-one with a melting point of 242°-45° C.

Provenance & Evidence