Sodium Acetate → HCID 12536141, compound

HRID 894848Notes

Reaction equation

HRID 894848 reaction equation
C(O[C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][C:7]1=[CH:12][C:13]#[N:14])=[O:5])C.Br.N[CH2:17][CH2:18][CH2:19][SH:20].C([O-])(=O)C.[Na+]>ClC1C=CC=CC=1Cl>[O:5]=[C:4]1[C:6]2[CH2:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:12]=[C:13]2[S:20][CH2:19][CH2:18][CH2:17][N:14]12

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 12218835HCID 12218835, compoundHCID 53806130HCID 53806130, compound

Product 1

HCID 12536141HCID 12536141, compound

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Procedure

To 15 ml. of o-dichlorobenzene were added 5.8 g. of 2-cyanomethylene-cyclohexane-carboxylic acid ethyl ester, 6.5 g. of 3-aminopropanethiol hydrobromide and 3.1 g. of sodium acetate. Then, by treating the mixture as in Example 95, 800 mg. of 6-oxo-3,4,7,8,9,10-hexahydro-2H,6H-1,3-thiazino[3,2-b]isoquinoline was obtained.

Workup

  1. additionThen, by treating the mixture as in Example 95, 800 mg

Sources & evidence

ORD record
ord-c4066e57384b498f9bb6837e63337f6e
Source dataset
uspto-grants-1981_08
Patent number
US04284778

Reaction notes

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