HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Proline 1,1-dimethylethyl ester → 5-Amino-2-mercaptomethylpentanoyl-L-leucine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| Reactant | tert-butyl (2S)-2-amino-4-methylpentanoate | HCID 7022311 | — |
| Reactant | N-[2-acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-Leucine tert-butyl ester | HCID 53738373 | — |
| Reactant | N-[2-acetylthiomethyl-5-aminopentanoyl]-L-leucine | HCID 53939363 | — |
| Reactant | N-(5-amino-2-mercaptomethylpentanoyl)-L-leucine | HCID 54226392 | — |
| Product | 5-Amino-2-mercaptomethylpentanoyl-L-leucine | HCID 86737957 | — |
Reaction Steps
By substituting L-leucine tert-butyl ester for the proline tert-butyl ester in the procedure of Example 13, and then submitting the product to the procedure of Examples 14 and 15, N-[2-acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-Leucine tert-butyl ester, N-[2-acetylthiomethyl-5-aminopentanoyl]-L-leucine and N-(5-amino-2-mercaptomethylpentanoyl)-L-leucine are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04284779 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-bdd9e1d42a4541be81b76a1a6f901883 |
| Source note | uspto-grants-1981_08 |