反应详情

温度

50 °C

To a solution of dimethylsulfoxonium methylide (69.4 mmoles) in dimethyl sulfoxide (65 ml.) at room temperature is added solid 3-l -dimethoxyacetophenone (8.33 g., 55.5 mmoles). The reaction mixture is stirred for one hour at 25° C., for one-half hour at 50° C. and is then cooled. The mixture is diluted with water (50 ml.) and added to a mixture of ice water (200 ml.)--ether (250 ml.)--low boiling petroleum ether (25 ml.). The organic extract is washed twice with water (250 ml.), dried (MgSO4) and evaporated to an oil which is fractionally distilled.

1. temperatureis then cooled
2. extractionThe organic extract
3. washis washed twice with water (250 ml.)
4. dry with materialdried (MgSO4)
5. customevaporated to an oil which
6. distillationis fractionally distilled