反应详情

26.25 ml 4 N NaOH (.105 mol) was added to a stirred mixture of 21.0 g (0.105 mol) 4-benzyloxyphenol and 22.5 g (0.1 mol) of 1-(2-chloroethyl)-4-phenylpiperazine in 250 ml DMSO and the reaction was heated at 60° for 60 min. After cooling, the stirred mixture was diluted with 50 ml 1 N NaOH solution and the resulting crystalline precipitate was collected by filtration and washed with water to give, after drying in vacuo, essentially pure end product, mp 116°-119°.

1. temperaturethe reaction was heated at 60° for 60 min
2. temperatureAfter cooling
3. filtrationthe resulting crystalline precipitate was collected by filtration
4. washwashed with water
5. customto give
6. customafter drying in vacuo, essentially pure end product, mp 116°-119°