p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

Participants

Reaction Steps

A hot solution of 0.95 g (5 mmoles) of p-toluenesulfonic acid hydrate in 5 ml of absolute ethanol was added to a hot suspension of 1.97 g (5 mmoles) of 4-amino-2-(4,4-dimethylimidazolidin-2-on-1-yl)-pyrimidine-5-carboxylic acid 3-trifluoromethyl-anilide in 40 ml of absolute ethanol; after this, a solution formed for a short time and this was boiled under reflux for 5 minutes. After cooling, the crystalline product which had precipitated was filtered off and washed with ethanol and ether. After drying, 2.52 g (86.3% yield) of the abovementioned p-toluenesulfonate of m.p. 223°-4° C. were obtained.

Provenance & Evidence